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Link to original content: http://pubmed.ncbi.nlm.nih.gov/15062640/
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Review
. 2004 May 3;28(5):395-413.
doi: 10.1016/j.dci.2003.09.005.

The molecular evolution of the interleukin-1 family of cytokines; IL-18 in teleost fish

Mark O Huising  1 , René J M Stet, Huub F J Savelkoul, B M Lidy Verburg-van Kemenade
Affiliations
Review

The molecular evolution of the interleukin-1 family of cytokines; IL-18 in teleost fish

Mark O Huising et al. Dev Comp Immunol. .

Abstract

The cytokine network is an important homeostatic system with potent activities in immune surveillance, growth, developmental and repair processes. Although interleukin-1beta (IL-1beta) is considered a pivotal pro-inflammatory cytokine, merely focussing on its inflammatory role would be too narrow an approach. Elucidation of the human, the mouse and the Fugu rubripes (pufferfish) genome now enables a more comprehensive overview of this cytokine family and its receptors in several vertebrate classes. Phylogenetic analyses of the IL-1 family members, comprising over 80 sequences of various fish, amphibian, avian and mammalian species, reveal that for only a few mammalian IL-1 family members unambiguous orthologues have been found in fish, indicating a recent origin of some of the mammalian IL-1 family members. Interestingly, the Fugu genome did reveal teleost orthologues for IL-18 and its putative receptor complex. All teleost IL-1beta sequences cluster separately from IL-1beta sequences of other species. In contrast, a number of IL-1 receptor family members have well conserved fish orthologues. This supports the concept of an ancestral role of this family, possibly in the brain.

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