PROSITE documentation PDOC51830FIIND domain profile
Description
The "Function to Find Domain" (FIIND)-containing proteins CARD8 (Cardinal; Tucan) and NLRP1 (NALP1; NAC) are well known components of inflammasomes, multiprotein complexes responsible for activation of caspase-1, a regulator of inflammation and innate immunity. CARD8 and NLRP1 undergo autoproteolytic cleavage at a conserved SF/S motif within the FIIND. The FIIND domain is only present in chordates and consists of a ZU5-like domain (see <PDOC51145>) and a UPA-like domain [1,2,3].
The profile we developed covers the entire FIIND domain.
Last update:March 2017 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Tschopp J. Martinon F. Burns K. |
| Title | NALPs: a novel protein family involved in inflammation. | |
| Source | Nat. Rev. Mol. Cell Biol. 4:95-104(2003). | |
| PubMed ID | 12563287 | |
| DOI | 10.1038/nrm1019 |
| 2 | Authors | D'Osualdo A. Weichenberger C.X. Wagner R.N. Godzik A. Wooley J. Reed J.C. |
| Title | CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain. | |
| Source | PLoS ONE 6:E27396-E27396(2011). | |
| PubMed ID | 22087307 | |
| DOI | 10.1371/journal.pone.0027396 |
| 3 | Authors | Liao Y. Pei J. Cheng H. Grishin N.V. |
| Title | An ancient autoproteolytic domain found in GAIN, ZU5 and Nucleoporin98. | |
| Source | J. Mol. Biol. 426:3935-3945(2014). | |
| PubMed ID | 25451782 | |
| DOI | 10.1016/j.jmb.2014.10.011 |
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