PROSITE documentation PDOC51758Letm1 ribosome-binding (RBD) domain profile
Mitochondrial ribosomes synthesize core subunits of the inner membrane respiratory chain complexes. In mitochondria, ribosomes are mainly membrane associated and translation is tightly coupled to the inner mitochondrial membrane. Mdm38/Letm1 is a conserved membrane receptor for mitochondrial ribosomes and specifically involved in respiratory chain biogenesis.
The Letm1 ribosome-binding domain (RBD) is necessary and sufficient for interaction with mitochondrial ribosomes. It exhibits a predominantly α-helical compact fold (see <PDB:3SKQ>) and contains extended, highly charged surface patches. The conserved regions most probably represent interaction sites for ribosomal RNA or protein subunits, or for proteins involved in mitochondrial protein biogenesis [1,2].
The profile we developed covers the entire Letm1 RBD domain.
Last update:May 2015 / First entry.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Lupo D. Vollmer C. Deckers M. Mick D.U. Tews I. Sinning I. Rehling P. |
| Title | Mdm38 is a 14-3-3-like receptor and associates with the protein synthesis machinery at the inner mitochondrial membrane. | |
| Source | Traffic 12:1457-1466(2011). | |
| PubMed ID | 21718401 | |
| DOI | 10.1111/j.1600-0854.2011.01239.x |
| 2 | Authors | Bauerschmitt H. Mick D.U. Deckers M. Vollmer C. Funes S. Kehrein K. Ott M. Rehling P. Herrmann J.M. |
| Title | Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation. | |
| Source | Mol. Biol. Cell 21:1937-1944(2010). | |
| PubMed ID | 20427570 | |
| DOI | 10.1091/mbc.E10-02-0101 |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
View entry in original PROSITE document format
View entry in raw text format (no links)