PROSITE documentation PDOC51269COMM domain profile
COMM (copper metabolism gene MURR1) domain proteins constitute a family initially identified as interacting partners of COMMD1 (previously known as MURR1), the prototype member of this protein family. COMMD1 is a multifunctional protein that has been shown to participate in two apparently distinct activities, regulation of the transcription factor NF-kappa-B and control of copper metabolism. The family is defined by the presence of a C-terminal motif termed COMM domain, which functions as an interface for protein-protein interactions. The proteins designated as COMMD or COMM domain containing 1-10 are extensively conserved in multicellular eukaryotic organisms [1,2].
The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a β-sheet [1].
The profile we developed covers the entire COMM domain.
Last update:November 2006 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Burstein E. Hoberg J.E. Wilkinson A.S. Rumble J.M. Csomos R.A. Komarck C.M. Maine G.N. Wilkinson J.C. Mayo M.W. Duckett C.S. |
| Title | COMMD proteins, a novel family of structural and functional homologs of MURR1. | |
| Source | J. Biol. Chem. 280:22222-22232(2005). | |
| PubMed ID | 15799966 | |
| DOI | 10.1074/jbc.M501928200 |
| 2 | Authors | de Bie P. van de Sluis B. Burstein E. Duran K.J. Berger R. Duckett C.S. Wijmenga C. Klomp L.W.J. |
| Title | Characterization of COMMD protein-protein interactions in NF-kappaB signalling. | |
| Source | Biochem. J. 398:63-71(2006). | |
| PubMed ID | 16573520 | |
| DOI | 10.1042/BJ20051664 |
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