PROSITE documentation PDOC01019Phosphatidate cytidylyltransferase signature
Description
Phosphatidate cytidylyltransferase (EC 2.7.7.41) [1,2,3] (also known as CDP-diacylglycerol synthase) (CDS) is the enzyme that catalyzes the synthesis of CDP-diacylglycerol from CTP and phosphatidate (PA). CDP-diacylglycerol is an important branch point intermediate in both prokaryotic and eukaryotic organisms. CDS is a membrane-bound enzyme. As a signature pattern we selected a conserved region located in the C-terminal part.
Last update:December 2004 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Sparrow C.P. Raetz C.R.H. |
| Title | Purification and properties of the membrane-bound CDP-diglyceride synthetase from Escherichia coli. | |
| Source | J. Biol. Chem. 260:12084-12091(1985). | |
| PubMed ID | 2995359 |
| 2 | Authors | Shen H. Heacock P.N. Clancey C.J. Dowhan W. |
| Title | The CDS1 gene encoding CDP-diacylglycerol synthase in Saccharomyces cerevisiae is essential for cell growth. | |
| Source | J. Biol. Chem. 271:789-795(1996). | |
| PubMed ID | 8557688 |
| 3 | Authors | Saito S. Goto K. Tonosaki A. Kondo H. |
| Title | Gene cloning and characterization of CDP-diacylglycerol synthase from rat brain. | |
| Source | J. Biol. Chem. 272:9503-9509(1997). | |
| PubMed ID | 9083091 |
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