PROSITE documentation PDOC00539recF protein signatures
The prokaryotic protein recF [1,2] is a single-stranded DNA-binding protein which also probably binds ATP. RecF is involved in DNA metabolism; it is required for recombinational DNA repair and for induction of the SOS response.
RecF is a protein of about 350 to 370 amino acid residues; there is a conserved ATP-binding site motif 'A' (P-loop) in the N-terminal section of the protein as well as two other conserved regions, one located in the central section, and the other in the C-terminal section. We have derived signature patterns from these two regions.
Last update:April 2006 / Pattern revised.
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PROSITE methods (with tools and information) covered by this documentation:
| 1 | Authors | Sandler S.J. Chackerian B. Li J.T. Clark A.J. |
| Title | Sequence and complementation analysis of recF genes from Escherichia coli, Salmonella typhimurium, Pseudomonas putida and Bacillus subtilis: evidence for an essential phosphate binding loop. | |
| Source | Nucleic Acids Res. 20:839-845(1992). | |
| PubMed ID | 1542576 |
| 2 | Authors | Alonso J.C. Fisher L.M. |
| Title | Nucleotide sequence of the recF gene cluster from Staphylococcus aureus and complementation analysis in Bacillus subtilis recF mutants. | |
| Source | Mol. Gen. Genet. 246:680-686(1995). | |
| PubMed ID | 7898435 |
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