PROSITE documentation PDOC00281Glycophorin A signature
Glycophorin A is the major sialoglycoprotein of erythrocyte membrane [1]. Structurally, glycophorin A consists of an N-terminal extracellular domain, heavily glycosylated on serine and threonine residues, followed by a transmembrane region and a C-terminal cytoplasmic domain.
In human there are two closely related forms: glycophorin A which carries the blood group M/N antigen, and glycophorin B which carries the blood group S/s antigen.
The best conserved region of glycophorin A is the transmembrane domain and we have derived a consensus pattern from that region.
Last update:December 1991 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Murayama J.-I. Utsumi H. Hamada A. |
| Title | Amino acid sequence of monkey erythrocyte glycophorin MK. Its amino acid sequence has a striking homology with that of human glycophorin A. | |
| Source | Biochim. Biophys. Acta 999:273-280(1989). | |
| PubMed ID | 2605264 |
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