PROSITE documentation PDOC00264Cyclins signature
Cyclins [1,2,3] are eukaryotic proteins which play an active role in controlling nuclear cell division cycles. Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins:
- G2/M cyclins, essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase).
- G1/S cyclins, essential for the control of the cell cycle at the G1/S (start) transition.
In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.
A cyclin homolog has also been found in herpesvirus saimiri [4].
The best conserved region is in the central part of the cyclins' sequences, known as the 'cyclin-box', from which we have derived a 32 residue pattern.
Last update:November 1995 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Nurse P. |
| Title | Universal control mechanism regulating onset of M-phase. | |
| Source | Nature 344:503-508(1990). | |
| PubMed ID | 2138713 |
| 2 | Authors | Norbury C. Nurse P. |
| Title | Cyclins and cell cycle control. | |
| Source | Curr. Biol. 1:23-24(1991). | |
| PubMed ID | 15336197 |
| 3 | Authors | Lew D.J. I Reed S. |
| Title | A proliferation of cyclins. | |
| Source | Trends Cell Biol. 2:77-81(1992). | |
| PubMed ID | 14731948 |
| 4 | Authors | Nicholas J. Cameron K.R. Honess R.W. |
| Title | Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins. | |
| Source | Nature 355:362-365(1992). | |
| PubMed ID | 1309943 | |
| DOI | 10.1038/355362a0 |
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