KMUP-1

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KMUP-1
Names
Preferred IUPAC name
7-{2-[4-(2-Chlorophenyl)piperazin-1-yl]ethyl}-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
Other names
7-[2-[4-(2-Chlorophenyl)piperazinyl]ethyl]-1,3-dimethylxanthine
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.211.655 Edit this at Wikidata
UNII
  • InChI=1S/C19H23ClN6O2/c1-22-17-16(18(27)23(2)19(22)28)26(13-21-17)12-9-24-7-10-25(11-8-24)15-6-4-3-5-14(15)20/h3-6,13H,7-12H2,1-2H3
    Key: NIDVDYQCGWISJZ-UHFFFAOYSA-N
  • CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CCN3CCN(CC3)C4=CC=CC=C4Cl
Properties
C19H23ClN6O2
Molar mass 402.88 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

KMUP-1 is a xanthine derivative with phosphodiesterase inhibitor activity.[1]

References

  1. ^ Liou, Shu-Fen; Hsu, Jong-Hau; Lin, I-Ling; Ho, Mei-Ling; Hsu, Pei-Chuan; Chen, Li-Wen; Chen, Ing-Jun; Yeh, Jwu-Lai (2013). "KMUP-1 suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss: roles of MAPKs, Akt, NF-κB and calcium/calcineurin/NFATc1 pathways". PLOS ONE. 8 (7): e69468. Bibcode:2013PLoSO...869468L. doi:10.1371/journal.pone.0069468. PMC 3723916. PMID 23936022.
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