KCNK15

KCNK15
Identifiers
Aliases	KCNK15, K2p15.1, KCNK11, KCNK14, KT3.3, TASK-5, TASK5, dJ781B1.1, potassium two pore domain channel subfamily K member 15
External IDs	OMIM: 607368; MGI: 2675209; HomoloGene: 11179; GeneCards: KCNK15; OMA:KCNK15 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	44,752,313 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	163,701,666 bp
RNA expression pattern
	Top expressed in
	thoracic aorta; ; ascending aorta; ; Descending thoracic aorta; ; left coronary artery; ; gonad; ; right coronary artery; ; popliteal artery; ; tibial arteries; ; right uterine tube; ; testicle;
	Top expressed in
	cumulus cell; ; olfactory bulb; ; sternocleidomastoid muscle; ; cerebellar cortex; ; superior frontal gyrus; ; submandibular gland; ; placenta;
	More reference expression data
	n/a
Gene ontology
Molecular function	voltage-gated ion channel activity; potassium channel activity; potassium ion leak channel activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	potassium ion transport; regulation of ion transmembrane transport; cardiac conduction; ion transport; stabilization of membrane potential; potassium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	60598
	241769
	ENSG00000124249
	ENSMUSG00000035238
	Q9H427
	n/a
	NM_022358
	NM_001030292
	NP_071753
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Potassium channel subfamily K member 15 is a protein that in humans is encoded by the KCNK15 gene.^[5]^[6]^[7]^[8]

This gene encodes K_2P15.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K_2P15.1 has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124249 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035238 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kim D, Gnatenco C (Jun 2001). "TASK-5, a new member of the tandem-pore K(+) channel family". Biochem Biophys Res Commun. 284 (4): 923–30. doi:10.1006/bbrc.2001.5064. PMID 11409881.
^ Vega-Saenz de Miera E, Lau DH, Zhadina M, Pountney D, Coetzee WA, Rudy B (Jun 2001). "KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1". J Neurophysiol. 86 (1): 130–42. doi:10.1152/jn.2001.86.1.130. PMID 11431495. S2CID 14855672.
^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.
^ ^a ^b "Entrez Gene: KCNK15 potassium channel, subfamily K, member 15".

External links

KCNK15+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124249 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035238 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11409881-5] Kim D, Gnatenco C (Jun 2001). "TASK-5, a new member of the tandem-pore K(+) channel family". Biochem Biophys Res Commun. 284 (4): 923–30. doi:10.1006/bbrc.2001.5064. PMID 11409881.

[pmid11431495-6] Vega-Saenz de Miera E, Lau DH, Zhadina M, Pountney D, Coetzee WA, Rudy B (Jun 2001). "KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1". J Neurophysiol. 86 (1): 130–42. doi:10.1152/jn.2001.86.1.130. PMID 11431495. S2CID 14855672.

[pmid16382106-7] Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. S2CID 7356601.

[entrez-8] "Entrez Gene: KCNK15 potassium channel, subfamily K, member 15".

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KCNK15

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KCNK15

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