FOXO6

FOXO6
Identifiers
Aliases	FOXO6, forkhead box O6
External IDs	OMIM: 611457; MGI: 2676586; HomoloGene: 82395; GeneCards: FOXO6; OMA:FOXO6 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.2 Start 41,361,922 bp End 41,383,590 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.1 Start 120,124,276 bp End 120,144,546 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence pituitary gland anterior pituitary testicle muscle of thigh right ovary left ovary left lobe of thyroid gland body of uterus placenta Top expressed in ganglionic eminence Claustrum ventricular zone subdivision of hippocampus quadriceps femoris muscle nucleus accumbens hippocampus proper skeletal muscle tissue cingulate gyrus Region I of hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity sequence-specific DNA binding Cellular component nucleus Biological process transcription, DNA-templated regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 100132074 329934 Ensembl ENSG00000204060 ENSG00000281518 ENSMUSG00000052135 UniProt A0A1X9RU27 Q70KY4 RefSeq (mRNA) NM_001291281 NM_194060 RefSeq (protein) NP_001278210 NP_918949 Location (UCSC) Chr 1: 41.36 – 41.38 Mb Chr 4: 120.12 – 120.14 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Forkhead box O6 is a protein that in humans is encoded by the FOXO6 gene.

FoxO6 is expressed in the liver, skeletal muscle, and the hippocampus of the brain. In the liver, FoxO6 normally promotes gluconeogenesis in the fasted state, but insulin blocks Fox06 upon feeding. In a condition of insulin resistance insulin fails to block FoxO6 resulting in continued gluconeogenesis even upon feeding.

Further reading

• Jacobs FM, van der Heide LP, Wijchers PJ, Burbach JP, Hoekman MF, Smidt MP (September 2003). "FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics". The Journal of Biological Chemistry. 278 (38): 35959–67. doi:10.1074/jbc.M302804200. PMID 12857750.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Kleindorp R, Flachsbart F, Puca AA, Malovini A, Schreiber S, Nebel A (August 2011). "Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans". Aging Cell. 10 (4): 622–8. doi:10.1111/j.1474-9726.2011.00698.x. PMID 21388494.
• Tzivion G, Dobson M, Ramakrishnan G (November 2011). "FoxO transcription factors; Regulation by AKT and 14-3-3 proteins". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1813 (11): 1938–45. doi:10.1016/j.bbamcr.2011.06.002. PMID 21708191.
• Kim DH, Perdomo G, Zhang T, Slusher S, Lee S, Phillips BE, Fan Y, Giannoukakis N, Gramignoli R, Strom S, Ringquist S, Dong HH (November 2011). "FoxO6 integrates insulin signaling with gluconeogenesis in the liver". Diabetes. 60 (11): 2763–74. doi:10.2337/db11-0548. PMC 3198083. PMID 21940782.
• Kim DH, Zhang T, Lee S, Dong HH (September 2013). "FoxO6 in glucose metabolism (FoxO6)". Journal of Diabetes. 5 (3): 233–40. doi:10.1111/1753-0407.12027. PMC 3657578. PMID 23324123.
• Qinyu L, Long C, Zhen-dong D, Min-min S, Wei-ze W, Wei-ping Y, Cheng-hong P (July 2013). "FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc". FEBS Letters. 587 (14): 2105–11. Bibcode:2013FEBSL.587.2105Q. doi:10.1016/j.febslet.2013.05.027. PMID 23714368. S2CID 38064268.