Bile salt sulfotransferase

SULT2A1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1EFH, 1J99, 1OV4, 2QP3, 2QP4, 3F3Y, 4IFB
Identifiers
Aliases	SULT2A1, DHEA-ST, DHEAS, HST, ST2, ST2A1, ST2A3, STD, hSTa, sulfotransferase family 2A member 1, DHEA-ST8, SULT2A3
External IDs	OMIM: 125263; MGI: 3645854; HomoloGene: 37741; GeneCards: SULT2A1; OMA:SULT2A1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	47,886,315 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	13,723,532 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; jejunal mucosa; ; right lobe of liver; ; left adrenal cortex; ; duodenum; ; gonad; ; buccal mucosa cell; ; seminal vesicula; ; cardia; ; mucosa of ileum;
	Top expressed in
	primary oocyte; ; zygote; ; secondary oocyte; ; spermatocyte; ; spermatid; ; gonad; ; testicle; ; liver;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; protein binding; estrone sulfotransferase activity; aryl sulfotransferase activity; steroid sulfotransferase activity; bile-salt sulfotransferase activity;
Cellular component	cytoplasm; cytosol;
Biological process	lipid catabolic process; bile acid catabolic process; sulfation; lipid metabolism; ethanol catabolic process; regulation of lipid metabolic process; 3'-phosphoadenosine 5'-phosphosulfate metabolic process; steroid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	6822
	434121
	ENSG00000105398
	ENSMUSG00000074377
	Q06520
	n/a
	NM_003167
	NM_001101534
	NP_003158
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.^[5]^[6]^[7]

Function

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene is primarily expressed in liver and adrenal tissues where the encoded protein sulfonates steroids and bile acids.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105398 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074377 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1".
^ Otterness DM, Wieben ED, Wood TC, Watson WG, Madden BJ, McCormick DJ, Weinshilboum RM (May 1992). "Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA". Mol. Pharmacol. 41 (5): 865–72. PMID 1588921.
^ Otterness DM, Mohrenweiser HW, Brandriff BF, Weinshilboum RM (1995). "Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3". Cytogenet. Cell Genet. 70 (1–2): 45–7. doi:10.1159/000133988. PMID 7736787.

Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. doi:10.1096/fasebj.11.1.9034160. PMID 9034160. S2CID 12532583.
Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112–113: 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID 10720750.
Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246.
Kong AN, Yang L, Ma M, et al. (1992). "Molecular cloning of the alcohol/hydroxysteroid form (hSTa) of sulfotransferase from human liver". Biochem. Biophys. Res. Commun. 187 (1): 448–54. doi:10.1016/S0006-291X(05)81514-1. PMID 1520333.
Comer KA, Falany CN (1992). "Immunological characterization of dehydroepiandrosterone sulfotransferase from human liver and adrenal". Mol. Pharmacol. 41 (4): 645–51. PMID 1569919.
Otterness DM, Wieben ED, Wood TC, et al. (1992). "Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA". Mol. Pharmacol. 41 (5): 865–72. PMID 1588921.
Radominska A, Comer KA, Zimniak P, et al. (1991). "Human liver steroid sulphotransferase sulphates bile acids". Biochem. J. 272 (3): 597–604. doi:10.1042/bj2720597. PMC 1149750. PMID 2268288.
Forbes KJ, Hagen M, Glatt H, et al. (1995). "Human fetal adrenal hydroxysteroid sulphotransferase: cDNA cloning, stable expression in V79 cells and functional characterisation of the expressed enzyme". Mol. Cell. Endocrinol. 112 (1): 53–60. doi:10.1016/0303-7207(95)03585-U. PMID 7589785. S2CID 39327051.
Luu-The V, Dufort I, Paquet N, et al. (1995). "Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene". DNA Cell Biol. 14 (6): 511–8. doi:10.1089/dna.1995.14.511. PMID 7598806.
Comer KA, Falany JL, Falany CN (1993). "Cloning and expression of human liver dehydroepiandrosterone sulphotransferase". Biochem. J. 289 (1): 233–40. doi:10.1042/bj2890233. PMC 1132155. PMID 7678732.
Otterness DM, Her C, Aksoy S, et al. (1995). "Human dehydroepiandrosterone sulfotransferase gene: molecular cloning and structural characterization". DNA Cell Biol. 14 (4): 331–41. doi:10.1089/dna.1995.14.331. PMID 7710689.
Otterness DM, Mohrenweiser HW, Brandriff BF, Weinshilboum RM (1995). "Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3". Cytogenet. Cell Genet. 70 (1–2): 45–7. doi:10.1159/000133988. PMID 7736787.
Falany CN, Wheeler J, Oh TS, Falany JL (1994). "Steroid sulfation by expressed human cytosolic sulfotransferases". J. Steroid Biochem. Mol. Biol. 48 (4): 369–75. doi:10.1016/0960-0760(94)90077-9. PMID 8142314. S2CID 37646598.
Barker EV, Hume R, Hallas A, Coughtrie WH (1994). "Dehydroepiandrosterone sulfotransferase in the developing human fetus: quantitative biochemical and immunological characterization of the hepatic, renal, and adrenal enzymes". Endocrinology. 134 (2): 982–9. doi:10.1210/endo.134.2.8299591. PMID 8299591.
Durocher F, Morissette J, Dufort I, et al. (1996). "Genetic linkage mapping of the dehydroepiandrosterone sulfotransferase (STD) gene on the chromosome 19q13.3 region". Genomics. 29 (3): 781–3. doi:10.1006/geno.1995.9935. PMID 8575776.
Rubin GL, Harrold AJ, Mills JA, et al. (1999). "Regulation of sulphotransferase expression in the endometrium during the menstrual cycle, by oral contraceptives and during early pregnancy". Mol. Hum. Reprod. 5 (11): 995–1002. doi:10.1093/molehr/5.11.995. PMID 10541560.
Tashiro A, Sasano H, Nishikawa T, et al. (2000). "Expression and activity of dehydroepiandrosterone sulfotransferase in human gastric mucosa". J. Steroid Biochem. Mol. Biol. 72 (3–4): 149–54. doi:10.1016/S0960-0760(00)00020-0. PMID 10775806. S2CID 44681209.
Pedersen LC, Petrotchenko EV, Negishi M (2000). "Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase". FEBS Lett. 475 (1): 61–4. doi:10.1016/S0014-5793(00)01479-4. PMID 10854859. S2CID 38252369.

External links

alcohol+sulfotransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human SULT2A1 genome location and SULT2A1 gene details page in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105398 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074377 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1".

[pmid1588921-6] Otterness DM, Wieben ED, Wood TC, Watson WG, Madden BJ, McCormick DJ, Weinshilboum RM (May 1992). "Human liver dehydroepiandrosterone sulfotransferase: molecular cloning and expression of cDNA". Mol. Pharmacol. 41 (5): 865–72. PMID 1588921.

[pmid7736787-7] Otterness DM, Mohrenweiser HW, Brandriff BF, Weinshilboum RM (1995). "Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3". Cytogenet. Cell Genet. 70 (1–2): 45–7. doi:10.1159/000133988. PMID 7736787.

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v t e Transferases: sulfur-containing group (EC 2.8)
2.8.1: Sulfurtransferases	Thiosulfate sulfurtransferase Rhodanese 3-mercaptopyruvate sulfurtransferase thiosulfate—thiol sulfurtransferase tRNA sulfurtransferase thiosulfate—dithiol sulfurtransferase biotin synthase cysteine desulfurase lipoyl synthase molybdenum cofactor sulfurtransferase thiazole synthase molybdopterin synthase sulfurtransferase molybdopterin synthase tRNA-uridine 2-sulfurtransferase () tRNA-5-taurinomethyluridine 2-sulfurtransferase () tRNA-5-methyluridine⁵⁴ 2-sulfurtransferase () L-aspartate semialdehyde sulfurtransferase ()
2.8.2: Sulfotransferases	aryl sulfotransferase amine sulfotransferase estrone sulfotransferase chondroitin 4-sulfotransferase choline sulfotransferase UDP-N-acetylgalactosamine-4-sulfate sulfotransferase heparan sulfate-glucosamine N-sulfotransferase tyrosine-ester sulfotransferase Renilla-luciferin sulfotransferase galactosylceramide sulfotransferase psychosine sulfotransferase bile salt sulfotransferase steroid sulfotransferase thiol sulfotransferase chondroitin 6-sulfotransferase cortisol sulfotransferase triglucosylalkylacylglycerol sulfotransferase protein-tyrosine sulfotransferase keratan sulfotransferase aryl-sulfate sulfotransferase (heparan sulfate)-glucosamine 3-sulfotransferase 1 desulfoglucosinolate sulfotransferase flavonol 3-sulfotransferase quercetin-3-sulfate 3′-sulfotransferase quercetin-3-sulfate 4′-sulfotransferase quercetin-3,3′-bissulfate 7-sulfotransferase (heparan sulfate)-glucosamine 3-sulfotransferase 2 (heparan sulfate)-glucosamine 3-sulfotransferase 3 petromyzonol sulfotransferase scymnol sulfotransferase N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase glycochenodeoxycholate sulfotransferase dermatan 4-sulfotransferase desulfo-A47934 sulfotransferase () trehalose 2-sulfotransferase () aliphatic desulfoglucosinolate sulfotransferase () hydroxyjasmonate sulfotransferase () ω-hydroxy-β-dihydromenaquinone-9 sulfotransferase (*) Alcohol sulfotransferase Tyrosylprotein sulfotransferase
2.8.3: CoA-transferases	Propionate CoA-transferase oxalate CoA-transferase malonate CoA-transferase 3-oxoacid CoA-transferase 3-oxoadipate CoA-transferase succinyl-CoA—Dcitramalate CoA-transferase acetate CoA-transferase butyrate—acetoacetate CoA-transferase citrate CoA-transferase citramalate CoA-transferase glutaconate CoA-transferase succinate—hydroxymethylglutarate CoA-transferase 5-hydroxypentanoate CoA-transferase succinyl-CoA:(R)-benzylsuccinate CoA-transferase formyl-CoA transferase cinnamoyl-CoA:phenyllactate CoA-transferase succinyl-CoA:acetate CoA-transferase () CoA:oxalate CoA-transferase () succinyl-CoA—D-citramalate CoA-transferase () L-carnitine CoA-transferase () succinyl-CoA—L-malate CoA-transferase () caffeate CoA-transferase () (R)-2-hydroxy-4-methylpentanoate CoA-transferase () bile acid CoA-transferase () succinyl-CoA:mesaconate CoA transferase (*)
2.8.4: Alkylthio	2.8.4: Coenzyme-B sulfoethylthiotransferase arsenate-mycothiol transferase tRNA-2-methylthio-N⁶-dimethylallyladenosine synthase () [ribosomal protein S12] (aspartate⁸⁹-C³)-methylthiotransferase () tRNA (N⁶-L-threonylcarbamoyladenosine³⁷-C²)-methylthiotransferase (*)
2.8.5:	2.8.5: S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent) () L-cysteine S-thiosulfotransferase ()

Bile salt sulfotransferase

Function

See also

References

Further reading

External links