Naltriben

Naltriben
Clinical data
ATC code	none;
Identifiers
CAS Number	111555-58-9 ;
PubChem CID	5486827;
IUPHAR/BPS	1640;
ChemSpider	4589081 ;
UNII	RXG719F189;
ChEMBL	ChEMBL100940 ;
PDB ligand	ZY8 (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID80912218 ;
Chemical and physical data
Formula	C26H25NO4
Molar mass	415.489 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc3c2O[C@H]6c1oc8ccccc8c1C[C@@]5(O)[C@H]4N(CC[C@@]56c2c(cc3)C4)CC7CC7;
	InChI InChI=1S/C26H25NO4/c28-18-8-7-15-11-20-26(29)12-17-16-3-1-2-4-19(16)30-22(17)24-25(26,21(15)23(18)31-24)9-10-27(20)13-14-5-6-14/h1-4,7-8,14,20,24,28-29H,5-6,9-13H2/t20-,24+,25+,26-/m1/s1 ; Key:ZHVWWEYETMPAMX-IFKAHUTRSA-N ;
	(verify)

Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ₁ and δ₂ subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors.^[1] It also acts as a κ-opioid agonist at high doses.^[2]

References

^ Sofuoglu M, Portoghese PS, Takemori AE (May 1991). "Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes". The Journal of Pharmacology and Experimental Therapeutics. 257 (2): 676–80. PMID 1851833.
^ Stewart PE, Holper EM, Hammond DL (1994). "Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes". Life Sciences. 55 (4): PL79-84. doi:10.1016/0024-3205(94)00738-1. PMID 8028443.

[1] Sofuoglu M, Portoghese PS, Takemori AE (May 1991). "Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes". The Journal of Pharmacology and Experimental Therapeutics. 257 (2): 676–80. PMID 1851833.

[2] Stewart PE, Holper EM, Hammond DL (1994). "Delta antagonist and kappa agonist activity of Naltriben: evidence for differential kappa interaction with the delta 1 and delta 2 opioid receptor subtypes". Life Sciences. 55 (4): PL79-84. doi:10.1016/0024-3205(94)00738-1. PMID 8028443.

[1]

[2]

See also

References