Magnesium taurate

Magnesium taurate
Names
	Preferred IUPAC name Magnesium bis(2-aminoethane-1-sulfonate)
	Other names Magnesium ditaurate
Identifiers
CAS Number	334824-43-0 ;
3D model (JSmol)	Interactive image;
ChemSpider	16432063;
PubChem CID	13343447;
UNII	RCM1N3D968 ;
CompTox Dashboard (EPA)	DTXSID201022013 ;
	InChI InChI=1S/2C2H7NO3S.Mg/c23-1-2-7(4,5)6;/h21-3H2,(H,4,5,6);/q;;+2/p-2 Key: YZURQOBSFRVSEB-UHFFFAOYSA-L;
	SMILES C(CS(=O)(=O)[O-])N.C(CS(=O)(=O)[O-])N.[Mg+2];
Properties
Chemical formula	C4H12MgN2O6S2
Molar mass	272.57 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). (what is ?) Infobox references

Magnesium taurate, also known as magnesium ditaurate or magnesium taurinate,^[1] is the magnesium salt of taurine, and a mineral supplement.

It contains approximately 8.9% elemental magnesium by mass. Accordingly, 100 mg of magnesium is contained in 1121 mg of magnesium taurate.

Safety

Due to the expected dissociation of magnesium taurate in the body before absorption, safety data on magnesium and taurine can be used to evaluate the safety of magnesium taurate.^[1]

Taurine has an observed safe level of supplemental intake in normal healthy adults at up to 3 g/day.^[2] Using the same level as an approximation for taurate yields a limit of 3.3 g/day for magnesium taurate, or alternatively 300 mg/day for elemental magnesium as taurate.

References

^ ^a ^b "Scientific Opinion of the Panel on Food Additives and Nutrient Sources added to Food on iron (II) taurate, magnesium taurate and magnesium acetyl taurate as sources for iron or magnesium to be added as a nutritional substance in food supplements following a request from the European Commission" (PDF). 2009. Synonyms for magnesium taurate are: magnesium taurinate, magnesium 2-aminoethane sulfonic acid and magnesium ditaurate. [...] Due to the expected dissociation of magnesium taurate in the body before absorption, data on magnesium and taurate (or taurine) can be used to evaluate the safety of magnesium taurate.
^ Shao A, Hathcock JN (2008). "Risk assessment for the amino acids taurine, L-glutamine and L-arginine". Regulatory Toxicology and Pharmacology. 50 (3): 376–99. doi:10.1016/j.yrtph.2008.01.004. PMID 18325648. the newer method described as the Observed Safe Level (OSL) or Highest Observed Intake (HOI) was utilized. The OSL risk assessments indicate that based on the available published human clinical trial data, the evidence for the absence of adverse effects is strong for Tau at supplemental intakes up to 3 g/d, Gln at intakes up to 14 g/d and Arg at intakes up to 20 g/d, and these levels are identified as the respective OSLs for normal healthy adults.

[efsa2009-1] "Scientific Opinion of the Panel on Food Additives and Nutrient Sources added to Food on iron (II) taurate, magnesium taurate and magnesium acetyl taurate as sources for iron or magnesium to be added as a nutritional substance in food supplements following a request from the European Commission" (PDF). 2009. Synonyms for magnesium taurate are: magnesium taurinate, magnesium 2-aminoethane sulfonic acid and magnesium ditaurate. [...] Due to the expected dissociation of magnesium taurate in the body before absorption, data on magnesium and taurate (or taurine) can be used to evaluate the safety of magnesium taurate.

[pmid18325648-2] Shao A, Hathcock JN (2008). "Risk assessment for the amino acids taurine, L-glutamine and L-arginine". Regulatory Toxicology and Pharmacology. 50 (3): 376–99. doi:10.1016/j.yrtph.2008.01.004. PMID 18325648. the newer method described as the Observed Safe Level (OSL) or Highest Observed Intake (HOI) was utilized. The OSL risk assessments indicate that based on the available published human clinical trial data, the evidence for the absence of adverse effects is strong for Tau at supplemental intakes up to 3 g/d, Gln at intakes up to 14 g/d and Arg at intakes up to 20 g/d, and these levels are identified as the respective OSLs for normal healthy adults.

[1]

[2]

Safety

See also

References