JZL195

JZL195
Names
	Preferred IUPAC name 4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate
Identifiers
CAS Number	1210004-12-8;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL606201;
ChemSpider	24655100;
PubChem CID	46232606;
UNII	TP6P2HKJ54 ;
CompTox Dashboard (EPA)	DTXSID401029877 ;
	InChI InChI=1S/C24H23N3O5/c28-24(32-22-11-9-20(10-12-22)27(29)30)26-15-13-25(14-16-26)18-19-5-4-8-23(17-19)31-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2 Key: QNYRAEKLMNDRFY-UHFFFAOYSA-N;
	SMILES c1ccc(cc1)Oc2cccc(c2)CN3CCN(CC3)C(=O)Oc4ccc(cc4)[N+](=O)[O-];
Properties
Chemical formula	C24H23N3O5
Molar mass	433.464 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

JZL195 is a potent inhibitor of both fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), the primary enzymes responsible for degrading the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively.^[1]

References

^ Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL, Cravatt BF (December 2009). "Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo". Proceedings of the National Academy of Sciences of the United States of America. 106 (48): 20270–5. Bibcode:2009PNAS..10620270L. doi:10.1073/pnas.0909411106. PMC 2787168. PMID 19918051.

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