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Link to original content: http://en.wikipedia.org/wiki/Guanidinoacetase
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Guanidinoacetase

From Wikipedia, the free encyclopedia
guanidinoacetase
Identifiers
EC no.3.5.3.2
CAS no.9024-92-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a guanidinoacetase (EC 3.5.3.2) is an enzyme that catalyzes the chemical reaction

guanidinoacetate + H2O glycine + urea

Thus, the two substrates of this enzyme are guanidinoacetate and H2O, whereas its two products are glycine and urea.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is guanidinoacetate amidinohydrolase. This enzyme is also called glycocyaminase. It employs one cofactor, manganese.

References

[edit]
  • ROCHE J, LACOMBE G, GIRARD H (1950). "[On the specificity of certain bacterial deguanidases generating urea and on arginindihydrolase.]". Biochim. Biophys. Acta. 6 (1): 210–6. doi:10.1016/0006-3002(50)90093-x. PMID 14791411.
  • Yorifuji T, Tamai H, Usami H (1977). "Purification, crystallization and properties of Mn2+ dependent guanidoacetate amidinohydrolase from a Pseudomonas". Agric. Biol. Chem. 41 (6): 959–966. doi:10.1271/bbb1961.41.959.