Talk:Lyme disease
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reference error
editnumber 27 links to a dead government link 68.51.184.18 (talk) 01:23, 14 November 2024 (UTC)
- Updated. --McSly (talk) 01:33, 14 November 2024 (UTC)
Wiki Education assignment: Special Topics- Lyme Disease
edit
This article is currently the subject of a Wiki Education Foundation-supported course assignment, between 26 August 2024 and 6 December 2024. Further details are available on the course page. Student editor(s): Meb59721 (article contribs).
— Assignment last updated by Meb59721 (talk) 20:25, 30 November 2024 (UTC)
@Russellpickle Thanks for your edits about a very difficult topic. I reverted your changes mostly because of the fringy claims about persisters (discussed by Baker and Marques) and alleged antibiotic resistance.
Wikipedia has guidelines for identifying reliable sources in medicine, called MEDRS. (See also Why MEDRS?) Caution is urged particularly when using studies that are in test tubes or animals, which may not be representative of human disease.
Also, research regarding PTLDS is often confounded because of anchoring to a Lyme diagnosis that may or may not have happened. Marques writes:
Once a patient has received the diagnosis of “chronic Lyme disease”, the inclination is to assign any signs and symptoms to it, leading to missed or delayed diagnosis of other medical conditions. Patients diagnosed with “chronic Lyme disease” can be reluctant to accept the diagnosis of other diseases, even when this can have dire consequences. These patients frequently disagree with the different diagnosis provided, seeking further evaluation and receiving additional antibiotic therapy for Lyme disease.
The majority of patients diagnosed with CLD have conditions whose symptoms are misdiagnosed or are patients with medically unexplained physical symptoms (MUPS) who receive the diagnosis based on unproven and/or non-validated laboratory tests and clinical criteria (Figure 2). Studies have shown that 47 to 80% of the patients seeking further evaluation for Lyme disease had no evidence of B. burgdorferi infection. An alternative diagnosis was made in 15 to 55% (median 34%) of the cases, while MUPS accounted for 19% to 54% (median 32%). Patients with PTLDs accounted for 3 to 15% (median 9%) of the cases. Patients with MUPS, or persistent physical symptoms, are common across general medicine.
In a controlled study in Europe, 27.2% of patients classified as Lyme disease had persistent symptoms, but so did 21.2% of the population and 23.3% of people with a tick bite. Some possible shortcomings of the study have been raised, but the overall conclusion is that there was "an association, either direct or indirect, between persistent symptoms and LB in a relatively small subset of patients." The CDC mentions this study on its overview written for a general audience.
Upon further consideration, I may have gone too far in reverting all your edits, and I hope that you can continue contributing. The Marques reference may be a helpful resource. This article could benefit from a section discussing the frequent false positive diagnoses and resultant over-treatment. ScienceFlyer (talk) 01:47, 4 December 2024 (UTC)