Cyclin E2 is a protein that in humans is encoded by the CCNE2 gene. It is a G1 cyclin that binds Cdk2 and is inhibited by p27(Kip1) and p21(Cip1).[1] It plays a role in the G1/S portion of the cell cycle and also has putative interactions with proteins CDKN1A, CDKN1B, and CDK3. Aberrant expression can lead to cancer.[1]
| cyclin E2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CCNE2 | ||||||
| NCBI gene | 9134 | ||||||
| HGNC | 1590 | ||||||
| OMIM | 603775 | ||||||
| RefSeq | NM_057749 | ||||||
| UniProt | O96020 | ||||||
| Other data | |||||||
| Locus | Chr. 8 q22.1 | ||||||
| |||||||
References
edit- ^ a b Gudas JM, Payton M, Thukral S, Chen E, Bass M, Robinson MO, Coats S (January 1999). "Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers". Molecular and Cellular Biology. 19 (1): 612–22. doi:10.1128/mcb.19.1.612. PMC 83919. PMID 9858585.
- Zariwala M, Liu J, Xiong Y (1998-11-26). "Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins". Oncogene. 17 (21): 2787–2798. doi:10.1038/sj.onc.1202505. ISSN 0950-9232. PMID 9840943. S2CID 7340570.