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Link to original content: http://dx.doi.org/10.1038/sj.onc.1208924
The role of TGF-β and Wnt signaling in gastrointestinal stem cells and cancer | Oncogene
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The role of TGF-β and Wnt signaling in gastrointestinal stem cells and cancer

Oncogene volume 24, pages 5775–5789 (2005)Cite this article

Abstract

The past three decades have seen an unremitting quest to identify and understand gastrointestinal stem cells, their plasticity in differentiating across cell types, as well as their role in normal, regenerative, and cancer cells. A fascinating hallmark of stem cells is their ability to undergo assymetric cell division, which entails replication of the DNA followed by division of the nucleus and partitioning of the cytoplasm to yield two different daughter cells: a stem cell as well as a committed progenitor cell, the latter proliferating into differentiated progeny. We are only just beginning to understand how normally quiescent, tissue-specific stem cells interpret a vast array of signals to develop into the gastrointestinal system. These signaling pathways include the transforming growth factor-β (TGF-β) superfamily, Wnt, FGFs, Hedgehog, Hox proteins that originate from surrounding mesodermal/stromal tissue as well as endodermal/epithelial tissue. TGF-β and wnt proteins are key morphogens that ultimately influence cell division and cell fate, so that gut endodermal stem cells enter the cell cycle, and undergo cell division that ultimately leads to differentiated cells such as functional hepatocytes, gastric parietal cells, or gut epithelial cells. Disruptions and errors in this process usually lead to tissue-specific gastrointestinal cancers such as hepatocellular cancers, gastric adenocarcinomas, and colonic adenocarcinomas. An increasingly complex and coherent view of stem/progenitor cell signaling networks, which coordinate cell growth, proliferation, stress management, and survival, is helping to define the fragile areas where malignancies are likely to develop and shows promise for the development of better cancer therapies.

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References

  • Accili D and Arden KC . (2004). Cell, 117, 421–426.

  • Akiyama Y, Iwanaga R, Saitoh K, Shiba K, Ushio K, Ikeda E, Iwama T, Nomizu T and Yuasa Y . (1997). Gastroenterology, 112, 33–39.

  • Alison MR, Poulsom R, Jeffery R, Dhillon AP, Quaglia A, Jacob J, Novelli M, Prentice G, Williamson J and Wright NA . (2000). Nature, 406, 257.

  • Alpini G, Alvaro D, Marzioni M, LeSage G and LaRusso N (eds) (2004). The Pathophysiology of Biliar Epithelia: Medical Intelligence Unit. Landes Biosciences: Georgetown, TX.

    Google Scholar 

  • Alvarez-Dolado M, Pardal R, Garcia-Verdugo JM, Fike JR, Lee HO, Pfeffer K, Lois C, Morrison SJ and Alvarez-Bullia A . (2003). Nature, 425, 968–973.

  • Attisano L and Wrana JL . (1998). Curr. Opin. Cell Biol., 10, 188–194.

  • Barnard JA, Beauchamp RD, Coffey RJ and Moses HL . (1989). PNAS, 86, 1578–1582.

  • Batlle E, Henderson JT, Beghtel H, van den Born MMW, Sancho E, Huls G, Meeldijk J, Robertson J, van de Wetering M, Pawson T and Clevers H . (2002). Cell, 111, 251–263.

  • Beck KA and Nelson WJ . (1996). Am. J. Physiol., 270, C1263–C1270.

  • Bennett V and Baines AJ . (2001). Physiol. Rev., 81, 1353–1392.

  • Bhowmick NA, Chytil A, Plieth D, Gorska AE, Dumont N, Shappell S, Washington MK, Neilson EG and Moses HL . (2004). Science, 303, 848–851.

  • Bissell MJ . (1981). Int. Rev. Cytol., 70, 27–100.

  • Bissell MJ, Hall HG and Parry G . (1982). J. Theor. Biol., 99, 31–68.

  • Bjerknes M and Cheng H . (1999). Am. J. Pathol., 154, 1831–1834.

  • Blau HM, Brazelton TR and Weimann JM . (2001). Cell, 105, 829–841.

  • Bonner-Weir S and Sharma A . (2002). J. Pathol., 197, 519–526.

  • Brittan M and Wright NA . (2002). J. Pathol., 197, 492–509.

  • Bronner CE, Baker SM, Morrison PT, Warren G, Smith LG, Lescoe MK, Kane M, Earabino C, Lipford J, Lindblom A, Tannergard P, Bollag RJ, Godwin AR, Ward DC, Nordenskjld M, Fishel R, Kolodner R and Liskay RM . (1994). Nature, 368, 258–261.

  • Chang J, Park K, Bang YJ, Won Seog K, Kim D and Kim SJ . (1997). Cancer Res., 57, 2856–2859.

  • Clements D, Rex M and Woodland HR . (2001). Int. Rev. Cytol., 203, 383–446.

  • Cohen P and Frame S . (2001). Nat. Rev. Mol. Cell Biol., 2, 769–776.

  • Cui W, Fowlis DJ, Bryson S, Duffie E, Ireland H, Balmain A and Akhurst RJ . (1996). Cell, 86, 531–542.

  • De Matteis MA and Morrow JS . (2000). J. Cell Sci., 113 (Part 13), 2331–2343.

  • Derynck R, Akhurst RJ and Balmain A . (2001). Nat. Genet., 29, 117–129.

  • Dolberg DS, Hollingsworth R, Hertle M and Bissell MJ . (1985). Science, 230, 676–678.

  • Dong C, Li Z, Alvarez Jr R, Feng XH and Goldschmidt-Clermont PJ . (2000). Mol. Cell, 5, 27–34.

  • Dubreuil RR, Grushko T and Baumann O . (2001). Cell Tissue Res., 306, 167–178.

  • Dubreuil RR, Wang P, Dahl S, Lee J and Goldstein LS . (2000). J. Cell Biol., 149, 647–656.

  • Edlund S, Lee SY, Grimsby S, Zhang S, Aspenstrom P, Heldin C-H and Land strom M . (2005). Mol. Cell. Biol., 25, 1475–1488.

  • Engel ME, McDonnell MA, Law BK and Moses HL . (1999). J. Biol. Chem., 274, 37413–37420.

  • Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL and Attisano L . (1996). Cell, 86, 543–552.

  • Fearon ER and Vogelstein B . (1990). Cell, 61, 759–767.

  • Fodde R, Smits R and Clevers H . (2001). Nat. Rev. Cancer, 1, 55–67.

  • Forbes S, Vig P, Poulsom R, Thomas H and Alison M . (2002). J. Pathol., 197, 510–518.

  • Furuhashi M, Yagi K, Yamamoto H, Furukawa Y, Shimada S, Nakamura Y, Kikuchi A, Miyazono K and Kato M . (2001). Mol. Cell. Biol., 21, 5132–5141.

  • Ganz T . (2000). Nat. Immunol., 1, 99–100.

  • Goggins M, Shekher M, Turnacioglu K, Yeo CJ, Hruban RH and Kern SE . (1998). Cancer Res., 58, 5329–5332.

  • Gold LI . (1999). Crit. Rev. Oncogenesis, 10, 303–360.

  • Grady W . (1998). Gastrointest Endosc., 48, 647–650.

  • Grady WM, Myeroff LL, Swinler SE, Rajput A, Thiagalingam S, Lutterbaugh JD, Neumann A, Brattain MG, Chang J, Kim SJ, Kinzler KW, Vogelstein B, Willson JK and Markowitz S . (1999). Cancer Res., 59, 320–324.

  • Grana X and Reddy EP . (1995). Oncogene, 11, 211–219.

  • Groden J, Thliveris A, Samowitz W, Carlson M, Gelbert L, Albertsen H, Joslyn G, Stevens J, Spirio L, Robertson M, Sargeant L, Krapcho K, Wolff E, Burt P, Hughes JP, Warrington J, McPherson J, Wasmuth J, LePaslier D, Abderrahim H, Cohen D, Leppert M and White R . (1991). Cell, 66, 589–600.

  • Haggitt RC and Reid BJ . (1986). Am J Surg Pathol, 10, 871–887.

  • Hahn SA, Bartsch D, Schroers A, Galehdari H, Becker M, Ramaswamy A, Schwarte-Waldhoff I, Maschek H and Schmiegel W . (1998). Cancer Res., 58, 1124–1126.

  • Hahn SA, Schutte M, Hoque AT, Moskaluk CA, da Costa LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH and Kern SE . (1996). Science, 271, 350–353.

  • Haramis A-PG, Begthel H, van den Born M, van Es J, Jonkheer S, Offerhaus GJA and Clevers H . (2004). Science, 303, 1684–1686.

  • He XC, Zhang J, Tong W-G, Tawfik O, Ross J, Scoville DH, Tian Q, Zeng X, He X, Wiedemann LM, Mishina Y and Li L . (2004). Nat. Genet., 36, 1117–1121.

  • Horne-Badovinac S, Rebagliati M and Stainier DYR . (2003). Science, 302, 662–665.

  • Houssaint E . (1981). Cell Differ., 10, 243–252.

  • Howe JR, Bair JL, Sayed MG, Anderson ME, Mitros FA, Petersen GM, Velculescu VE, Traverso G and Vogelstein B . (2001). Nat. Genet., 28, 184–187.

  • Howe JR, Roth S, Ringold JC, Summers RW, Jarvinen HJ, Sistonen P, Tomlinson IP, Houlston RS, Bevan S, Mitros FA, Stone EM and Aaltonen LA . (1998). Science, 280, 1086–1088.

  • Hu X and Zuckerman KS . (2001). J. Hematother. Stem Cell Res., 10, 67–74.

  • Huang J, Papadopoulos N, McKinley AJ, Farrington SM, Curtis LJ, Wyllie AH, Zheng S, Willson JKV, Markowitz SD, Morin P, Kinzler KW, Vogelstein B and Dunlop MG . (1996). PNAS, 93, 9049–9054.

  • Ianus A, Holz GG, Theise ND and Hussain MA . (2003). J. Clin. Invest., 111, 843–850.

  • Izzi L and Attisano L . (2004). Oncogene, 23, 2071–2078.

  • Jacoby RF, Schlack S, Sekhon G and Laxova R . (1997). Am. J. Med. Genet., 70, 361–364.

  • Jemal A, Thomas A, Murray T and Thun M . (2002). CA Cancer J. Clin., 52, 23–47.

  • Karam SM . (1999). Front. Biosci., 4, D286–D298.

  • Kinzler KW and Vogelstein B . (1998). Science, 280, 1036–1037.

  • Korbling M, Katz RL, Khanna A, Ruifrok AC, Rondon G, Albitar M, Champlin RE and Estrov Z . (2002). N. Engl. J. Med., 346, 738–746.

  • Koyama SY and Podolsky DK . (1989). J. Clin. Invest., 83, 1768–1773.

  • Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S and Sharkis SJ . (2001). Cell, 105, 369–377.

  • Labbe E, Letamendia A and Attisano L . (2000). Proc. Natl. Acad. Sci. USA, 97, 8358–8363.

  • Lagasse E, Connors H, Al-Dhalimy M, Reitsma M, Dohse M, Osborne L, Wang X, Finegold M, Weissman IL and Grompe M . (2000). Nat. Med., 6, 1229–1234.

  • Le Douarin N and Houssaint E . (1967). CR Acad. Sci. Hebd. Seances Acad. Sci. D, 264, 1872–1874.

  • Leach FS, Nicolaides NC, Papadopoulos N, Liu B, Jen J, Parsons R, Peltomaki P, Sistonen P, Aaltonen LA, Nystrom-Lahti M, Guan XY, Zhang J, Meltzer PS, Yu JW, Kao FT, Chen DJ, Cerosaletti KM, Fournier RE, Todd S, Lewis T, Leach RJ, Naylor SL, Weissenbach J, Mecklin JP, Jarvinen H, Peterson GM, Hamilton SR, Green J, Jass J, Watson P, Lynch HT, Trent JM, de la Chapelle A, Kinzler KW and Vogelstein B (1993). Cell, 75, 1215–1225.

  • Lemire JM, Shiojiri N and Fausto N . (1991). Am. J. Pathol., 139, 535–552.

  • Lengyel JA and Liu XJ . (1998). Cell Res., 8, 273–284.

  • Libbrecht L, De Vos R, Cassiman D, Desmet V, Aerts R and Roskams T . (2001). Am. J. Surg. Pathol., 1388–1396.

  • Libbrecht L, Desmet V, Van Damme B and Roskams T . (2000). J. Pathol., 192, 373–378.

  • Liu D, Kang JS and Derynck R . (2004). EMBO J., 23, 1557–1566.

  • Lu SL, Zhang WC, Akiyama Y, Nomizu T and Yuasa Y . (1996). Cancer Res., 56, 4595–4598.

  • Lynch HT and de la Chapelle A . (2003). N. Engl. J. Med., 348, 919–932.

  • Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B, Brattain M and Willson JKV . (1995). Science, 268, 1336–1338.

  • Marshman E, Booth C and Potten CS . (2002). Bioessays, 24, 91–98.

  • Massague J . (2004). Nature, 432, 298–306.

  • Massague J, Blain SW and Lo RS . (2000). Cell, 103, 295–309.

  • Matsumoto A, Hashimoto K, Yoshioka T and Otani H . (2002) 205, 53–65.

  • Mishra B, Tang Y, Katuri V, Fleury T, Said AH, Rashid A, Jogunoori W and Mishra L . (2004). Liver Int., 24, 637–645.

  • Mishra L, Cai T, Levine A, Weng D, Mezey E, Mishra B and Gearhart J . (1998). Int. J. Dev. Biol., 42, 221–224.

  • Miyaki M, Iijima T, Konishi M, Sakai K, Ishii A, Yasuno M, Hishima T, Koike M, Shitara N, Iwama T, Utsunomiya J, Kuroki T and Mori T . (1999). Oncogene, 18, 3098–3103.

  • Monga SP, Tang Y, Candotti F, Rashid A, Wildner O, Mishra B, Iqbal S and Mishra L . (2001). Cell Transplant., 10, 81–89.

  • Moses HL, Yang EY and Pietenpol JA . (1991). Ciba Found. Symp., 157, 66–74 discussion 75–80.

  • Murphy SJ, Dore JJ, Edens M, Coffey RJ, Barnard JA, Mitchell H, Wilkes M and Leof EB . (2004). Mol. Biol. Cell, 15, 2853–2862.

  • Murtaugh LC and Melton DA . (2003). Annu. Rev. Cell Dev. Biol., 19, 71–89.

  • Nagase H and Nakamura Y . (1993). Hum. Mutat., 2, 425–434.

  • Nakao A, Afrakhte M, Morn A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin N-E, Heldin C-H and Dijke PT . (1997). Nature, 389, 631–635.

  • Nakao A, Okumura K and Ogawa H . (2002). Trends Mol. Med., 8, 361–363.

  • Nucci MR, Robinson CR, Longo P, Campbell P and Hamilton SR . (1997). Hum. Pathol., 28, 1396–1407.

  • Oft M, Heider K-H and Beug H . (1998). Curr. Biol., 8, 1243–1252.

  • Parsons R, Myeroff LL, Liu B, Willson JK, Markowitz SD, Kinzler KW and Vogelstein B . (1995). Cancer Res., 55, 5548–5550.

  • Pasche B, Kolachana P, Nafa K, Satagopan J, Chen YG, Lo RS, Brener D, Yang D, Kirstein L, Oddoux C, Ostrer H, Vineis P, Varesco L, Jhanwar S, Luzzatto L, Massague J and Offit K . (1999). Cancer Res., 59, 5678–5682.

  • Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, Boggs SS, Greenberger JS and Goff JP . (1999). Science, 284, 1168–1170.

  • Poon RYC, Lew J and Hunter T . (1997). J. Biol. Chem., 272, 5703–5708.

  • Potten CS and Loeffler M . (1990). Development, 110, 1001–1020.

  • Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, Vogelstein B and Kinzler KW . (1992). Nature, 359, 235–237.

  • Preston SL, Wong W-M, Chan AO-O, Poulsom R, Jeffery R, Goodlad RA, Mandir N, Elia G, Novelli M, Bodmer WF, Tomlinson IP and Wright NA . (2003). Cancer Res., 63, 3819–3825.

  • Radisky DC and Bissell MJ . (2004). Science, 303, 775–777.

  • Radtke F and Clevers H . (2005). Science, 307, 1904–1909.

  • Rashid A, Houlihan P, Booker S, Petersen G, Giardiello F and Hamilton S . (2000). Gastroenterology, 119, 323–332.

  • Redman RS, Katuri V, Tang Y, Dillner A, Mishra B and Mishra L . (2005). J. Oral Pathol. Med., 34, 23–29.

  • Reiss M . (1997). Oncol. Res., 9, 447–457.

  • Roberts AB . (1999). Microbes Infect., 1, 1265–1273.

  • Roberts DJ . (2000). Dev. Dyn., 219, 109–120.

  • Rorke EA, Zhang D, Choo CK, Eckert RL and Jacobberger JW . (2000). Exp. Cell Res., 259, 149–157.

  • Roskams TA, Libbrecht L and Desmet VJ . (2003). Semin. Liver Dis., 23, 385–396.

  • Sancho E, Batlle E and Clevers H . (2003). Curr. Opin. Cell Biol., 15, 763–770.

  • Satterwhite DJ and Neufeld KL . (2004). Cell Cycle, 3, 1069–1073.

  • Schutte M, Hruban RH, Hedrick L, Cho KR, Nadasdy GM, Weinstein CL, Bova GS, Isaacs WB, Cairns P, Nawroz H, Sidransky D, Casero Jr RA, Meltzer PS, Hahn SA and Kern SE . (1996). Cancer Res., 56, 2527–2530.

  • Seoane J, Le HV, Shen L, Anderson SA and Massague J . (2004). Cell, 117, 211.

  • Shafritz DA and Hadziyannis SJ . (1987). Monogr. Pathol., 28, 136–152.

  • Sherr CJ . (1996). Science, 274, 1672–1677.

  • Shi Y and Massague J . (2003). Cell, 113, 685–700.

  • Shih I-M, Wang T-L, Traverso G, Romans K, Hamilton SR, Ben-Sasson S, Kinzler KW and Vogelstein B . (2001). PNAS, 98, 2640–2645.

  • Siegel PM and Massague J . (2003). Nat. Rev. Cancer, 3, 807–821.

  • Siegel PM, Shu W and Massague J . (2003). J. Biol. Chem., 278, 35444–35450.

  • Sieweke MH, Thompson NL, Sporn MB and Bissell MJ . (1990). Science, 248, 1656–1660.

  • Simon TC and Gordon JI . (1995). Curr. Opin. Genet. Dev., 5, 577–586.

  • Slack JM . (1995). Development, 121, 1569–1580.

  • Sormunen RT, Leong AS, Vaaraniemi JP, Fernando SS and Eskelinen SM . (1999). J. Pathol., 187, 416–423.

  • Sporn MB and Roberts AB . (1988). Nature, 332, 217–219.

  • Sporn MB and Roberts AB . (1990). Ann. NY Acad. Sci., 593, 1–6.

  • Spradling A, Drummond-Barbosa D and Kai T . (2001). Nature, 414, 98–104.

  • Stainier DYR . (2002). Genes Dev., 16, 893–907.

  • Stainier DYR . (2005). Science, 307, 1902–1904.

  • Sternlicht MD, Lochter A, Sympson CJ, Huey B, Rougier JP, Gray JW, Pinkel D, Bissell MJ and Werb Z . (1999). Cell, 98, 137–146.

  • Takaku K, Oshima M, Miyoshi H, Matsui M, Seldin MF and Taketo MM . (1998). Cell, 92, 645–656.

  • Takenoshita S, Tani M, Nagashima M, Hagiwara K, Bennett WP, Yokota J and Harris CC . (1997). Oncogene, 14, 1255–1258.

  • Taketo MM and Takaku K . (2000). Cytokine Growth Factor Rev., 11, 147–157.

  • Tang B, Bottinger EP, Jakowlew SB, Bagnall KM, Mariano J, Anver MR, Letterio JJ and Wakefield LM . (1998). Nat. Med., 4, 802–807.

  • Tang Y, Katuri V, Dillner A, Mishra B, Deng CX and Mishra L . (2003). Science, 299, 574–577.

  • Tang Y, Katuri V, Srinivasan R, Fogt F, Redman R, Anand G, Said A, Fishbein T, Zasloff M, Reddy EP, Mishra B and Mishra L . (2005). Cancer Res., 65, 4228–4237.

  • Theise ND and Krause DS . (2002). Semin. Cell Dev. Biol., 13, 411–417.

  • Theise ND, Badve S, Saxena R, Henegariu O, Sell S, Crawford JM and Krause DS . (2000). Hepatology, 31, 235–240.

  • Theise ND, Saxena R, Portmann BC, Thung SN, Yee H, Chiriboga L, Kumar A and Crawford JM . (1999). Hepatology, 30, 1425–1433.

  • Thiagalingam S, Lengauer C, Leach FS, Schutte M, Hahn SA, Overhauser J, Willson JK, Markowitz S, Hamilton SR, Kern SE, Kinzler KW and Vogelstein B . (1996). Nat. Genet., 13, 343–346.

  • Thibodeau SN, Bren G and Schaid D . (1993). Science, 260, 816–819.

  • Tosh D and Strain A . (2005). J. Hepatol., 42, S75–S84.

  • Tran H, Brunet A, Griffith EC and Greenberg ME . (2003). Sci. STKE, 172, RE5.

  • Tsukazaki T, Chiang TA, Davison AF, Attisano L and Wrana JL . (1998). Cell, 95, 779.

  • Vassilopoulos G, Wang PR and Russell DW . (2003). Nature, 422, 901–904.

  • Villanueva A, Garcia C, Paules AB, Vicente M, Megias M, Reyes G, De Villalonga P, Agell N, Lluis F, Bachs O and Capella G . (1998). Oncogene, 17, 1969–1978.

  • Wang J, Sun L, Myeroff L, Wang X, Gentry LE, Yang J, Liang J, Zborowska E, Markowitz S, Willson JKV and Brattain MG . (1995). J. Biol. Chem., 270, 22044–22049.

  • Wang X, Foster M, Al-Dhalimy M, Lagasse E, Finegold M and Grompe M . (2003). Proc. Natl. Acad. Sci. USA, 100 (Suppl 1), 11881–11888.

  • Weimann JM, Johansson CB, Trejo A and Blau HM . (2003). Nat. Cell Biol., 5, 959–966.

  • Weinstein M, Monga SP, Liu Y, Brodie SG, Tang Y, Li C, Mishra L and Deng CX . (2001). Mol. Cell. Biol., 21, 5122–5131.

  • Wells JM and Melton DA . (1999). Annu. Rev. Cell Dev. Biol., 15, 393–410.

  • Wrana JL . (2000). Cell, 100, 189–192.

  • Xu X, Brodie SG, Yang X, Im YH, Parks WT, Chen L, Zhou YX, Weinstein M, Kim SJ and Deng CX . (2000). Oncogene, 19, 1868–1874.

  • Yang W, Velcich A, Lozonschi I, Liang J, Nicholas C, Zhuang M, Bancroft L and Augenlicht LH . (2005). Am. J. Pathol., 166, 1239–1246.

  • Yang X, Li C, Xu X and Deng C . (1998). PNAS, 95, 3667–3672.

  • Younes M, Harris AS and Morrow JS . (1989). Am. J. Pathol., 135, 1197–1212.

  • Zaret KS . (1996). Annu. Rev. Physiol., 58, 231–251.

  • Zhou XP, Woodford-Richens K, Lehtonen R, Kurose K, Aldred M, Hampel H, Launonen V, Virta S, Pilarski R, Salovaara R, Bodmer WF, Conrad BA, Dunlop M, Hodgson SV, Iwama T, Jarvinen H, Kellokumpu I, Kim JC, Leggett B, Markie D, Mecklin JP, Neale K, Phillips R, Piris J, Rozen P, Houlston RS, Aaltonen LA, Tomlinson IP and Eng C . (2001). Am. J. Hum. Genet., 69, 704–711.

  • Zhu Y, Richardson JA, Parada LF and Graff JM . (1998). Cell, 94, 703–714.

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Acknowledgements

We would like to acknowledge Amanda Elson, Tiffany Blake and Vidhya Murugesan for their help with this article. This work was supported by Sally Funderberg award, NIH Grants RO1 DK56111 (LM), RO1 DK58637 (BM), RO1 DK58196 (S.B.), RO1 CA106614 and VA Merit Award (LM).

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  1. Department of Surgery, Laboratory of GI Developmental Biology, Medicine and The Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA

    Lopa Mishra, Kirti Shetty & Yi Tang

  2. DVAMC, 50 Irving Street NW, Washington, DC, USA

    Lopa Mishra

  3. Department of Oncology, The Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA

    August Stuart & Stephen W Byers

  4. Department of Cell Biology, The Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA

    August Stuart & Stephen W Byers

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Mishra, L., Shetty, K., Tang, Y. et al. The role of TGF-β and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene 24, 5775–5789 (2005). https://doi.org/10.1038/sj.onc.1208924

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