The Randolph family of Virginia is a prominent political family, whose members contributed to the politics of Colonial Virginia and Virginia after statehood. They are descended from the Randolphs of Morton Morrell, Warwickshire, England. The first Randolph in America was Henry Randolph in 1643. His nephew, William Randolph, later came to Virginia as an orphan in 1669. He made his home at Turkey Island along the James River. Because of their numerous progeny, William Randolph and his wife, Mary Isham Randolph, have been referred to as "the Adam and Eve of Virginia". The Randolph family was the wealthiest and most powerful family in 18th-century Virginia.