Holly Jayne Stein is an American geologist who is a senior research scientist and a professor at Colorado State University. She established the AIRIE (Applied Isotope Research for Industry and the Environment) Program and has led the center since 1995. Her research focuses on the development of the rhenium-osmium (Re-Os) geochronometers. In 2015, she was elected Geochemistry Fellow of the European Association of Geochemistry.