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About: Effective half-life
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In pharmacokinetics, the effective half-life is the rate of accumulation or elimination of a biochemical or pharmacological substance in an organism; it is the analogue of biological half-life when the kinetics are governed by multiple independent mechanisms. This is seen when there are multiple mechanisms of elimination, or when a drug occupies multiple pharmacological compartments. It reflects the cumulative effect of the individual half-lives, as observed by the changes in the actual serum concentration of a drug under a given dosing regimen. The complexity of biological systems means that most pharmacological substances do not have a single mechanism of elimination, and hence the observed or effective half-life does not reflect that of a single process, but rather the summation of mult

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  • In pharmacokinetics, the effective half-life is the rate of accumulation or elimination of a biochemical or pharmacological substance in an organism; it is the analogue of biological half-life when the kinetics are governed by multiple independent mechanisms. This is seen when there are multiple mechanisms of elimination, or when a drug occupies multiple pharmacological compartments. It reflects the cumulative effect of the individual half-lives, as observed by the changes in the actual serum concentration of a drug under a given dosing regimen. The complexity of biological systems means that most pharmacological substances do not have a single mechanism of elimination, and hence the observed or effective half-life does not reflect that of a single process, but rather the summation of multiple independent processes. (en)
  • En el contexto de la Física nuclear, se entiende por periodo de semidesintegración o semivida el tiempo necesario para que el número de núclidos (N) presentes en una muestra radiactiva se reduzca a la mitad. Este intervalo de tiempo se considera constante debido a que la velocidad de desintegración (actividad radiactiva, A) no se mantiene sino que al ser directamente proporcional al número de núclidos (A=λN, siendo λ lo que se conoce como constante de desintegración, característica de cada especie radiactiva) disminuirá a medida que el número de núclidos vaya descendiendo. Así, podemos considerar la semivida como una magnitud intensiva, esto es, que no depende de la cantidad de núclidos existentes en la muestra. (es)
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  • En el contexto de la Física nuclear, se entiende por periodo de semidesintegración o semivida el tiempo necesario para que el número de núclidos (N) presentes en una muestra radiactiva se reduzca a la mitad. Este intervalo de tiempo se considera constante debido a que la velocidad de desintegración (actividad radiactiva, A) no se mantiene sino que al ser directamente proporcional al número de núclidos (A=λN, siendo λ lo que se conoce como constante de desintegración, característica de cada especie radiactiva) disminuirá a medida que el número de núclidos vaya descendiendo. Así, podemos considerar la semivida como una magnitud intensiva, esto es, que no depende de la cantidad de núclidos existentes en la muestra. (es)
  • In pharmacokinetics, the effective half-life is the rate of accumulation or elimination of a biochemical or pharmacological substance in an organism; it is the analogue of biological half-life when the kinetics are governed by multiple independent mechanisms. This is seen when there are multiple mechanisms of elimination, or when a drug occupies multiple pharmacological compartments. It reflects the cumulative effect of the individual half-lives, as observed by the changes in the actual serum concentration of a drug under a given dosing regimen. The complexity of biological systems means that most pharmacological substances do not have a single mechanism of elimination, and hence the observed or effective half-life does not reflect that of a single process, but rather the summation of mult (en)
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  • Periodo de semidesintegración efectivo (es)
  • Effective half-life (en)
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