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Link to original content: http://dbpedia.org/data/Metanephrine.jrdf
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Beide Substanzen entstehen aus ihren Vorg\u00E4ngern durch Wirkung des Enzyms Catechol-O-Methyltransferase (COMT), wobei die Konfiguration erhalten bleibt. Sie werden zum Teil direkt als Konjugate im Harn ausgeschieden, der andere Teil wird mittels des Enzyms Monoaminooxidase (MAO) weiter zum 3-Methoxy-4-hydroxymandels\u00E4urealdehyd desaminiert, welcher dann in einem weiteren Schritt entweder zu Vanillinmandels\u00E4ure (VMS) oxidiert oder zu 3-Methoxy-4-hydroxyphenylglycol (MHPG, MOPEG) reduziert wird, die dann ebenfalls mit dem Harn ausgeschieden werden." , "lang" : "de" } , { "type" : "literal", "value" : "\u8B8A\u814E\u4E0A\u817A\u7D20 (Metanephrine, metadrenaline) \u662F\u814E\u4E0A\u817A\u7D20\u7D93\u7531\u513F\u8336\u915A-O-\u7532\u57FA\u8F6C\u79FB\u9176(COMT)\u4F5C\u7528\u5F8C\u7522\u751F\u7684\u4EE3\u8B1D\u7522\u7269\u30022002\u5E74\u300A\u7F8E\u56FD\u533B\u5B66\u4F1A\u6742\u5FD7\u300B\u7684\u4E00\u7BC7\u6587\u7AE0\u6307\u51FA\u6E2C\u91CF\u8840\u6DB2\u4E2D\u7684\u8B8A\u814E\u4E0A\u817A\u7D20\u985E\u5206\u5B50(\u5305\u542B\u8B8A\u814E\u4E0A\u817A\u7D20\u4EE5\u53CA\u53BB\u7532\u8B8A\u814E\u4E0A\u817A\u7D20)\u662F\u8A3A\u65B7\u55DC\u927B\u7D30\u80DE\u7624(\u814E\u4E0A\u817A\u9AD3\u8CEA\u7684\u65B0\u751F\u7269)\u7684\u6700\u4F73\u65B9\u5F0F\u3002" , "lang" : "zh" } , { "type" : "literal", "value" : "Metanefrina \u00E9 um metabolito da epinefrina (adrenalina) que resulta da ac\u00E7\u00E3o da enzima catecol-O-metil transferase sobre a adrenalina. N\u00EDveis aumentados de metanefrina no sangue podem ser encontrados em pacientes que sofrem de feocromocitoma, ou outros tumores neuroend\u00F3crinos." , "lang" : "pt" } , { "type" : "literal", "value" : "La Metanefrina (metadrenalina) es un metabolito de la epinefrina (adrenalina) producido por la acci\u00F3n de la enzima catecol-O-metiltransferasa sobre la epinefrina. Un art\u00EDculo en el Journal of the American Medical Association, del a\u00F1o 2002, indicaba que la medici\u00F3n de los niveles de metanefrinas libres en el plasma es la mejor herramienta para el diagn\u00F3sitco del feocromocitoma, una neoplasia de la m\u00E9dula adrenal.\u200B" , "lang" : "es" } , { "type" : "literal", "value" : "\u30E1\u30BF\u30CD\u30D5\u30EA\u30F3(Metanephrine)\u307E\u305F\u306F\u30E1\u30BF\u30C9\u30EC\u30CA\u30EA\u30F3(Metadrenaline)\u306F\u3001\u30A2\u30C9\u30EC\u30CA\u30EA\u30F3\u306E\u4EE3\u8B1D\u7269\u8CEA\u3067\u3001\u30A2\u30C9\u30EC\u30CA\u30EA\u30F3\u306B\u30AB\u30C6\u30B3\u30FC\u30EB-O-\u30E1\u30C1\u30EB\u30C8\u30E9\u30F3\u30B9\u30D5\u30A7\u30E9\u30FC\u30BC\u304C\u4F5C\u7528\u3059\u308B\u3053\u3068\u3067\u751F\u3058\u308B\u30022002\u5E74\u306EJournal of the American Medical Association\u306B\u63B2\u8F09\u3055\u308C\u305F\u8AD6\u6587\u3067\u3001\u8840\u6F3F\u4E2D\u306E\u30E1\u30BF\u30CD\u30D5\u30EA\u30F3\u985E\uFF08\u30E1\u30BF\u30CD\u30D5\u30EA\u30F3\u53CA\u3073\u30CE\u30EB\u30E1\u30BF\u30CD\u30D5\u30EA\u30F3\uFF09\u306E\u904A\u96E2\u6FC3\u5EA6\u306E\u6E2C\u5B9A\u306F\u3001\u526F\u814E\u9AC4\u8CEA\u306E\u65B0\u751F\u7269\u3067\u3042\u308B\u8910\u8272\u7D30\u80DE\u816B\u306E\u6700\u826F\u306E\u8A3A\u65AD\u30C4\u30FC\u30EB\u3067\u3042\u308B\u3053\u3068\u304C\u793A\u3055\u308C\u305F\u3002 \n* \u30A2\u30C9\u30EC\u30CA\u30EA\u30F3" , "lang" : "ja" } , { "type" : "literal", "value" : "\uBA54\uD0C0\uB124\uD504\uB9B0(\uC601\uC5B4: metanephrine) \uB610\uB294 \uBA54\uD0C0\uB4DC\uB808\uB0A0\uB9B0(\uC601\uC5B4: metadrenaline)\uC740 \uC5D0\uD53C\uB124\uD504\uB9B0(\uC544\uB4DC\uB808\uB0A0\uB9B0)\uC5D0 \uCE74\uD14C\uCF5C-O-\uBA54\uD2F8\uD2B8\uB79C\uC2A4\uD37C\uB808\uC774\uC2A4\uAC00 \uC791\uC6A9\uD558\uC5EC \uC0DD\uC131\uB418\uB294 \uC5D0\uD53C\uB124\uD504\uB9B0\uC758 \uBD84\uD574 \uACFC\uC815\uC5D0\uC11C\uC758 \uB300\uC0AC\uC0B0\uBB3C\uC774\uB2E4. 2002\uB144 \uC5D0 \uBC1C\uD45C\uB41C \uD55C \uB17C\uBB38\uC5D0 \uB530\uB974\uBA74 \uBA54\uD0C0\uB124\uD504\uB9B0 \uBD84\uC790\uAD70(\uBA54\uD0C0\uB124\uD504\uB9B0\uACFC \uB178\uB974\uBA54\uD0C0\uB124\uD504\uB9B0\uC744 \uD3EC\uD568)\uC758 \uD608\uC7A5 \uC790\uC720 \uB18D\uB3C4 \uCE21\uC815\uC774 \uBD80\uC2E0\uC18D\uC9C8 \uC2E0\uC0DD\uBB3C\uC778 \uD06C\uB86C\uCE5C\uD654\uC138\uD3EC\uC885\uC758 \uC9C4\uB2E8\uC5D0 \uAC00\uC7A5 \uC88B\uC740 \uC218\uB2E8\uC774\uB77C\uACE0 \uC9C0\uC801\uD588\uB2E4." , "lang" : "ko" } , { "type" : "literal", "value" : "Metanephrine (metadrenaline) is a metabolite of epinephrine (adrenaline) created by action of catechol-O-methyl transferase on epinephrine. An article in the Journal of the American Medical Association, 2002, indicated that the measurement of plasma free levels of the metanephrines group of molecules (including metanephrine and normetanephrine) is the best tool in the diagnosis of pheochromocytoma, an adrenal medullary neoplasm. \n* epinephrine" , "lang" : "en" } , { "type" : "literal", "value" : "\u0645\u064A\u062A\u0627\u0646\u0641\u0631\u064A\u0646 \u0647\u0648 \u0645\u0631\u0643\u0628 \u0643\u064A\u0645\u064A\u0627\u0626\u064A \u0639\u0636\u0648\u064A \u0635\u064A\u063A\u062A\u0647 C10H15NO3\u060C \u0648\u064A\u0633\u0645\u0649 \u0648\u0641\u0642 \u0642\u0648\u0627\u0639\u062F \u0627\u0644\u062A\u0633\u0645\u064A\u0629 \u0627\u0644\u0646\u0638\u0627\u0645\u064A\u0629 \u0639\u0644\u0649 \u0627\u0644\u0634\u0643\u0644: 4-(1-\u0647\u064A\u062F\u0631\u0648\u0643\u0633\u064A-2-\u0645\u064A\u062B\u064A\u0644 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American Medical Association\u306B\u63B2\u8F09\u3055\u308C\u305F\u8AD6\u6587\u3067\u3001\u8840\u6F3F\u4E2D\u306E\u30E1\u30BF\u30CD\u30D5\u30EA\u30F3\u985E\uFF08\u30E1\u30BF\u30CD\u30D5\u30EA\u30F3\u53CA\u3073\u30CE\u30EB\u30E1\u30BF\u30CD\u30D5\u30EA\u30F3\uFF09\u306E\u904A\u96E2\u6FC3\u5EA6\u306E\u6E2C\u5B9A\u306F\u3001\u526F\u814E\u9AC4\u8CEA\u306E\u65B0\u751F\u7269\u3067\u3042\u308B\u8910\u8272\u7D30\u80DE\u816B\u306E\u6700\u826F\u306E\u8A3A\u65AD\u30C4\u30FC\u30EB\u3067\u3042\u308B\u3053\u3068\u304C\u793A\u3055\u308C\u305F\u3002 \n* \u30A2\u30C9\u30EC\u30CA\u30EA\u30F3" , "lang" : "ja" } , { "type" : "literal", "value" : "\u041C\u0435\u0442\u0430\u043D\u0435\u0444\u0440\u0438\u043D \u2014 \u043C\u0435\u0442\u0430\u0431\u043E\u043B\u0438\u0442 \u0430\u0434\u0440\u0435\u043D\u0430\u043B\u0438\u043D\u0430, \u043E\u0431\u0440\u0430\u0437\u0443\u0435\u043C\u044B\u0439 \u0441 \u043F\u043E\u043C\u043E\u0449\u044C\u044E \u0444\u0435\u0440\u043C\u0435\u043D\u0442\u0430 COMT." , "lang" : "ru" } , { "type" : "literal", "value" : "Als Metanephrine bezeichnet man zwei Methylierungsprodukte der Katecholamine Adrenalin, das Metanephrin, und Noradrenalin, das Normetanephrin. Beide Substanzen entstehen aus ihren Vorg\u00E4ngern durch Wirkung des Enzyms Catechol-O-Methyltransferase (COMT), wobei die Konfiguration erhalten bleibt. Sie werden zum Teil direkt als Konjugate im Harn ausgeschieden, der andere Teil wird mittels des Enzyms Monoaminooxidase (MAO) weiter zum 3-Methoxy-4-hydroxymandels\u00E4urealdehyd desaminiert, welcher dann in einem weiteren Schritt entweder zu Vanillinmandels\u00E4ure (VMS) oxidiert oder zu 3-Methoxy-4-hydroxyphenylglycol (MHPG, MOPEG) reduziert wird, die dann ebenfalls mit dem Harn ausgeschieden werden. Racemisches Metanephrin wird synthetisch hergestellt, das Hydrochlorid hat die CAS-Nummer 881-95-8." , "lang" : "de" } , { "type" : "literal", "value" : "Metanephrine (metadrenaline) is a metabolite of epinephrine (adrenaline) created by action of catechol-O-methyl transferase on epinephrine. An article in the Journal of the American Medical Association, 2002, indicated that the measurement of plasma free levels of the metanephrines group of molecules (including metanephrine and normetanephrine) is the best tool in the diagnosis of pheochromocytoma, an adrenal medullary neoplasm. \n* epinephrine" , "lang" : "en" } , { "type" : "literal", "value" : "Metanefrina \u00E9 um metabolito da epinefrina (adrenalina) que resulta da ac\u00E7\u00E3o da enzima catecol-O-metil transferase sobre a adrenalina. N\u00EDveis aumentados de metanefrina no sangue podem ser encontrados em pacientes que sofrem de feocromocitoma, ou outros tumores neuroend\u00F3crinos." , "lang" : "pt" } , { "type" : "literal", "value" : "La Metanefrina (metadrenalina) es un metabolito de la epinefrina (adrenalina) producido por la acci\u00F3n de la enzima catecol-O-metiltransferasa sobre la epinefrina. 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