Tramadol

Drug Usage Statistics, United States, 2013 - 2022

Tramadol Summary for 2022

Top drug rank	#55 ( 14)
Estimated number of prescriptions in the United States (2022)	12,203,197
Estimated number of patients in the United States (2022)	4,050,454

Average total drug cost (USD)
Per prescription	$16.03
Per day of therapy	$1.26/day
Average out-of-pocket cost (USD)
Per prescription	$4.15
Per day of therapy	$0.32/day

Total Prescriptions and Patients Per Year (2013 - 2022)

Rank of Top Drugs Over Time

"Rank" refers to the frequency that a given medication is prescribed within a calendar year compared to all other medications. A rank of "4" would indicate that the medication was the fourth most commonly prescribed medication.

Year	Rank	Change
2013	29	1
2014	24	5
2015	27	3
2016	38	11
2017	31	7

Year	Rank	Change
2018	25	6
2019	35	10
2020	35	0
2021	41	6
2022	55	14

Drug Cost Over Time (2013 - 2022)

Cost Per Prescription Fill: Average cost per filled prescription regardless of how many days of therapy the prescription is filled for (e.g. 10 days, 30 days, 90 days, etc.)
Cost per Day of Therapy: The average cost per prescription fill divided by the days of therapy. For example, a 10-day antibiotic course costing $30 would be $3 per day. Similarly, a 30-day supply of an oral antihypetensive costing $30 would be $1 per day.

Total cost: The average total cost of the medication including the out-of-pocket cost (see below) plus the amount paid by other parties (Medicare, Medicaid, private insurance, Veterans Administration, TRICARE, other state/federal sources, Worker's compensation, and other miscellaneous sources)
Out-of-pocket cost: The average payment made by the patient which may include deductibles, coinsurance, copayments, or the cash price paid without insurance coverage.

Cost Per Prescription Fill (USD)

Cost Per Day of Therapy (USD/day)

Distribution of Dispensed Dosage Forms (2022)

Dosage Form	Strength	% of Dispensed Products
Tablet/capsule	50 mg	98.9%
Other, unspecified, or misc.		1.1%

Distribution of Days Supplied (2022)

"Days supply" is defined as the number of days that a prescription should last. For example, a prescription of 60 tablets that is taken twice daily has a day supply of 30 days.

Related Drugs

Drug Name	Total Prescriptions (2022)
Acetaminophen; Hydrocodone	23,521,229
Tramadol (this drug)	12,203,198
Oxycodone	11,314,082
Acetaminophen; Oxycodone	6,531,256
Morphine	4,101,413
Acetaminophen; Codeine	3,179,642
Hydromorphone	1,531,449
Codeine; Guaifenesin	862,861
Loperamide	410,959
Homatropine; Hydrocodone	45,484
Hydrocodone; Chlorpheniramine	39,773
Codeine; Phenylephrine; Promethazine	26,799

Therapeutic Classes

Drug Synonyms

Drug synonyms are used during the sanitation and standardization process of "cleaning" the original data source (MEPS). Occassionally, brand names may be listed below that are no longer on the market or are very infrequently used.

Brand Name Synonyms

Conzip
Qdolo
Rybix Odt
Ryzolt
Ultram
Ultram ER

Generic Drug Synonyms and Salts

Tramadol Hydrochloride
Tramadol

FDA Approval Information

Established Pharmacologic Class (EPC):	Opioid Agonist
Initial FDA approval date:	3/3/1995
First FDA applicant:	Discn
First dosage form:	Tablet (oral)

Prescription data source: Medical Expenditure Panel Survey (MEPS) 2013-2022. Agency for Healthcare Research and Quality (AHRQ), Rockville, MD. ClinCalc DrugStats Database version 2024.08. Read more about the ClinCalc DrugStats database.

All ClinCalc DrugStats figures and graphs on this page are licensed under Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0).

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Updated Sep 12, 2021

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