Sequence and organization of the human mitochondrial genome
Abstract
The complete sequence of the 16,569-base pair human mitochondrial genome is presented. The genes for the 12S and 16S rRNAs, 22 tRNAs, cytochrome c oxidase subunits I, II and III, ATPase subunit 6, cytochrome b and eight other predicted protein coding genes have been located. The sequence shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
- Publication:
-
Nature
- Pub Date:
- April 1981
- DOI:
- 10.1038/290457a0
- Bibcode:
- 1981Natur.290..457A