CancerRob Bradbury This volume reviews advances in cancer chemotherapy research over the last 10 years. Chapters written by leading experts in their field reflect a range of current medicinal chemistry approaches to small molecule drugs. Each chapter covers the drug target and biological rationale, chemotypes, clinical status and future prospects in this rapidly developing area of drug research. |
Contents
| 1 | |
Principles of Endocrine Therapy of Cancer | 19 |
Inhibition of Growth Factor Signaling | 83 |
GarciaEcheverria | 169 |
Progress in the Development of Agents to Control the Cell Cycle | 207 |
Development of Angiogenesis Inhibitors | 333 |
Novel SmallMolecule Inhibitors of Src Kinase for Cancer Therapy | 383 |
Author Index Volume 1 | 445 |
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Acad Sci USA activity agents analogs angiogenesis Annu Meeting antagonists antitumor apoptosis assay Aurora-A autophosphorylation Bcr-Abl Biochem Biol Chem biological Bioorg Med Chem breast cancer cancer cells CDK2 CDK2/cyclin E IC50 CDK4 cell lines cellular Chem Lett Clin Cancer Res Clin Oncol clinical trials compound crystal structure Curr domain dose drug effects EGFR enzyme ErbB2 erlotinib estrogen farnesyl FTase FTIs gefitinib growth factor HDAC inhibitors histone IC50 values IGF-IR imatinib inhibition interaction kinase inhibitors lapatinib leukemia mg/day mg/kg mice molecule mutations Natl Acad Sci Oncogene oral pathway patients phase phosphorylation PI3K plasma preclinical Proc Natl Acad proliferation prostate cancer protein kinase response selective signaling sorafenib Src kinase stable disease steroid hormone receptors studies tamoxifen target therapeutic therapy toxicity treatment tumor tumor cell tumor growth tyrosine kinase VEGF vitro vivo Wang xenograft xenograft models